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KMID : 1199120080320010001
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Korean Diabetes Journal
2008 Volume.32 No. 1 p.1 ~ p.6
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Insulin Resistance in Polycystic Ovary Syndrome
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Sung Yeon-Ah
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Abstract
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Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women of reproductive age and
now recognized as an important metabolic and reproductive disorder. The majority of women with PCOS
have insulin resistance and this is regarded to have a central etiological role in PCOS. Insulin resistance and
concomitant hyperinsulinemia modifies reproductive function by driving androgen production, suppression of
sex hormone-binding globulin (SHBG) and disruption of insulin signaling pathways in the central nervous
system. Insulin resistance, together with defects in insulin secretion, confers markedly increased risk for type
2 diabetes mellitus and metabolic syndrome. There are post-binding defects in insulin receptor signaling, with
selective resistance to insulin’s metabolic actions and preserved other actions. Genetic and environmental
abnormalities interact to produce peripheral insulin resistance in PCOS. The numerous in vivo and in vitro data
supporting the central role of insulin resistance in the pathogenesis of PCOS have led a new therapy for PCOS
with insulin-sensitizing agents.
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KEYWORD
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Polycystic ovary syndrome, Insulin resistance
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